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What Are Biologics? Biologics work by mimicking substances naturally made by your immune system. These drugs are manufactured using genetic engineering, which means that certain genes—those that would normally guide the production of human immune system proteins—are produced artificially in large amounts. Because these drugs are active antibodies, they must be injected in the skin or given intravenously (through a vein). Most biologics for psoriatic disease are given by self-injection....

HARTWELL: You are born with a certain set of genes, so the most you can get out of DNA is inherited risk. The exception is cancer, where there are some DNA changes during the course of the disease. But you’re pretty much limited to biopsying the tumor to find the DNA, and if you’re interested in early detection or even signs of increased risks, you don’t have a tumor to biopsy....

As The Game Awards 2021 comes closer, there have been substantial leaks and rumors about BioShock 4 and what fans could expect from it. Some of those rumors point to a big reveal coming from The Game Awards, but there are others that go into more detail about what the game itself might look like. It’s always wise to take rumors with a grain of salt, but it’s hard to deny how some of them make BioShock 4 look like a promising entry in the acclaimed series....

It seems like there’s a new rumor on BioShock 4 every other week at this point, but all of those rumors have painted a very pretty picture of the overall game. From an open-world design to a setting in the deep reaches of outer space, BioShock 4 has the potential to really shake up the franchise. While it may be exciting to see BioShock 4 do something new, however, it should still feel like it’s a part of the BioShock world....

BioShock is the game being speedrun and BloodThunder is the speedrunner. He’s just over 30 minutes into the game when he reaches a point in the game where he uses a key to override a self-destruct sequence. Doing this is supposed to trigger a cutscene in-game, but something surprising happens instead. When BloodThunder uses the key, a Windows blue screen of death pops up, causing everyone in the room to suddenly hold their breath....

As with any series that continues to expand over a long period of time, specific points in the lore become unintentionally retconned. New fans of the series can overlook these retconned plot points, but they make those who have followed the series’ story since the early games scratch their heads. 6 Who Murdered Maria? The G.U.N Army, a reoccurring military group in Sonic The Hedgehog, isn’t too well-liked by fans for a myriad of reasons....

There have been several controversial moments to take place over the course of the year, ones that shocked and amazed the general public. From rumored feuds to celebrity court battles being available to watch in real time, here are some of the biggest moments of 2022. Biggest TV, Film and Celebrity Controversies of 2022 That Left Us Speechless 1. Will Smith Slaps Chris Rock at the 2022 Oscars When the 2022 Oscars began on March 27, no one could have expected the way things would go....

In an upcoming interview with NBC Nightly News, Barr told Lester Holt that he doubted Trump’s claims of election fraud, calling them “bulls**t” in the process. In a heated exchange, the former Trump ally said that if Trump could not accept that election fraud claims were not real, Barr would have to resign. “Then, boom, he slaps the desk,” Barr said, “and then he said, ‘accepted, accepted.’ And then, boom, he slapped again....

"I'm in favor of total preparation for the players for the season," Belichick said during a conference call with Buffalo reporters this week in leading up to Sunday's home game against the Bills. "And I think that's been changed significantly and, I would say, not necessarily for the better when you look at the injury numbers." MORE: Sunday’s season-ending schedule | VIDEO: Previews, news, more Belichick said players are more vulnerable to being hurt because they're less prepared, and described the limits placed on offseason workouts — including training camp — as being counterproductive....

It’s been ten years since Rep. Jim Nussle (R-Iowa) endured his own freshman blues. But the memory was vivid enough that he declared his first hearing as new chairman of the House Budget Committee on Wednesday “Freshman Day,” and invited some of the 41 first-year members of the 107th Congress to talk about what was on their minds. “Freshmen typically bring a vitality and exuberance to Congress,” said Nussle, “and we need to hear their ideas about writing the new budget....

In 2022, the “Ocean Eyes” star will top the bill at the English music festival, taking to the renowned Pyramid Stage on the Friday night of the five day event. Eilish shared the news via Instagram with a post showing a photograph of herself smiling in a Glastonbury hoodie, captioned “2022.” Emily Eavis, co-organizer of Glastonbury confirmed the news and said she “couldn’t be happier.” “We couldn’t be happier to announce that the wondrous @billieeilish is headlining the Pyramid on the Friday at next year’s Glastonbury Festival, becoming the youngest solo headliner in our history,” Eavis tweeted....

The team cut defensive back Leodis McKelvin, it announced on Friday. MORE: Top 50 players in 2016 Draft | Jones not expecting to be back with Packers The 30-year-old played in just nine games last year due to a lingering ankle injury he sustained during the 2014 season. Overall, he appeared in just 19 games over the last two years. The move frees up $3.9 million in cap room, which gives the Bills about $13 million total in cap space....

The Bills acquired Benjamin from the Carolina Panthers in November 2017 for third- and seventh-round picks in the 2018 NFL Draft. Benjamin was the 28th overall selection by the Panthers in 2014 and this season caught 23 passes for 354 yards and a touchdown. Buffalo also cut wide receiver Andre Holmes on Tuesday. 0 votes

RELATED: Top 10 Permadeath Games While some fans claim the new expansion is much more difficult than Afterbirth or Afterbirth+, there are many new items that either flat out break the game or combine well with just about anything. Edmund McMillen, the creator of the game, even said that the new meta’s difficulty is meant to force fans to try new methods of completing runs. Updated August 18, 2021 by Erik Petrovich: Part of what makes The Binding of Isaac: Repentance so replayable is the completely unique items that the new DLC gives players....

James I. Hudson, the study’s lead investigator and the director of the Biological Psychiatry Laboratory at the Harvard-affiliated McLean Hospital, spoke to NEWSWEEK’s Samantha Henig about the surprise findings in this study and what the results tell us about body image and the growing obesity epidemic. Excerpts: NEWSWEEK: Your survey found that binge eating is a much more common disorder than anorexia or bulimia. If that’s the case, why don’t we hear more about binge eating?...

Luckily, in late 2019, their questions were answered. It was announced that Cloud Chamber, a division of 2K, would be bringing BioShock 4 to life. Since reveal, not much else has been seen of BioShock 4 in the intervening years, and fans are getting more than a little impatient for news of the next installment. While an actual release date may not be set for any time soon, it seems increasingly likely that players will at least have some more details about the upcoming BioShock 4 this summer....

There’s one key way that the BioShock games have executed their environmental storytelling, specifically, which needs to be updated in BioShock 4. Fortunately, new development studio Cloud Chamber has plenty of ways it could achieve this. RELATED: 15 Action RPGs To Play If You Like BioShock Audio Diaries Audio diaries are the backbone of BioShock’s environmental storytelling. Renamed Voxophones for BioShock: Infinite’s early 1900s World Fair aesthetic, the only way to understand the full story of any BioShock game so far has been to search for and to listen to as many audio diaries as possible....

Although both BioShock and BioShock 2 are both being remastered for PS4, Xbox One, and PC; the third game in the series is only getting the remastered treatment for consoles. PC users will still receive Infinite in the Collection bundle, but it will be the same port that has been available since launch. Although PC gamers may feel a bit left out, 2K Games still needs to show off what new polish the team was able to throw onto Infinite in the three years since the game originally launched on consoles....

The listing from parent company Take-Two Interactive is for a Senior Producer for Ghost Story Games. It asks for someone who is “empathetic with the player” and “consistently pushes for quality game experiences that build lasting relationships.” Considering the cinematic qualities of Irrational Games’ works, particularly with the Bioshock series, it appears that the studio is looking to maintain its reputation for narrative-focused games with strong world building. RELATED: Borderlands 2, Bioshock Dev Reveals What Makes a Good Shooter...

Dermatologists have told Newsweek some of the most common myths are when it comes to looking after our skin. Myth: Pore vacuums and pore strips will shrink pores One common myth is that using pore vacuums or pore strips repeatedly will shrink your pores—the tiny openings in the skin that release oils and sweat. “Your pores are your pores, they don’t open and close like windows,” Fatima Fahs, a board-certified dermatologist in Michigan and found of Dermy Doc Box, told Newsweek....